80 Results for "

Juniperus occidentalis Hook.

" in MedChemExpress (MCE) Product Catalog:
Products (80)

80 Results for "Juniperus occidentalis Hook." in MCE Product Catalog:

6
6 Publications Verification
Art. -Nr.: HY-N0590
CAS. Nr.: 630-94-4
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
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4
4 Cited Publications
Art. -Nr.: HY-32736
CAS. Nr.: 38647-11-9
Synonyms: NSC 165677; PG 492
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
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4
4 Cited Publications
Art. -Nr.: HY-N0901
CAS. Nr.: 6877-32-3
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
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1
1 Cited Publications
Art. -Nr.: HY-N2411
CAS. Nr.: 60314-89-8
Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
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Art. -Nr.: HY-121618
CAS. Nr.: 546-80-5
Reinheit:  98.07%
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and can cross the blood-brain barrier .
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Art. -Nr.: HY-Y1110H
CAS. Nr.: 7786-30-3
Synonyms: Magnogene, suitable for insect cell culture
Magnesium chloride anhydrous, suitable for insect cell culture is an inorganic salt and cell culture medium component that can be used to prepare Tris buffer. Magnesium chloride anhydrous, suitable for insect cell culture is a component of Hunter's Thrips medium, which supports the in vitro culture of western flower thrip embryonic cells, and promotes the adhesion of tissue fragments/cells as well as the growth of fibroblast-like and epithelial-like cells .
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Art. -Nr.: HY-N5132
CAS. Nr.: 7787-20-4
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes CYP2A6 and CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP2B6 .
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Art. -Nr.: HY-118020A
CAS. Nr.: 5989-02-6
Reinheit:  99.72%
Synonyms: Loliolid; Digiprolactone
Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease .
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Art. -Nr.: HY-N5037
CAS. Nr.: 109008-27-7
Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .
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Art. -Nr.: HY-152261
CAS. Nr.: 2891709-58-1
Reinheit:  99.2%
Forschungsgebiete:  

Cancer

MS6105 is a PROTAC degrader targeting LDHA and LDHB, with DC50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research .
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Art. -Nr.: HY-N11493
CAS. Nr.: 32455-43-9
Hypolaetin 7-glucoside is a flavone glucoside that can be found in berries of Juniperus macropoda .
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Art. -Nr.: HY-N0476
CAS. Nr.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .
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Art. -Nr.: HY-161108
CAS. Nr.: 2597167-34-3
Forschungsgebiete:  

Cancer

PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
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Art. -Nr.: HY-N3441
CAS. Nr.: 86548-91-6
Junipediol A is a natural product, that can be isolated from the aerial parts of Juniperus phcenicea .
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Art. -Nr.: HY-N4307
CAS. Nr.: 72361-67-2
Laetanine is a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity. Laetanine can be found in the extract of the leaves of Phoebe tavoyana (Meissn) Hook .
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Art. -Nr.: HY-N1072
CAS. Nr.: 37239-47-7
Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system .
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Art. -Nr.: HY-162331
Target:  

Molecular Glues STING

Forschungsgebiete:  

Inflammation/Immunology Cancer

STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
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Art. -Nr.: HY-W1121877
CAS. Nr.: 28231-03-0
Cedrenol is a sesquiterpene alcohol compound found in Juniperus virginiana .
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Art. -Nr.: HY-N3142
CAS. Nr.: 865887-46-3
Oleuropeic acid 8-O-glucoside is a terpenic compound, that can be isolated from twigs with leaves of Juniperus communis var. depressa. Oleuropeic acid 8-O-glucoside shows antibacterial activity against three strains of Helicobacter pylori (NCTC11637, NCTC11916, and OCO1), with MIC of 100 μg/mL all .
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Art. -Nr.: HY-N6256
CAS. Nr.: 108906-69-0
Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC50 values of 48.8 μM and 477.5 μM, respectively .
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